Ganglion Cell-Inner Plexiform Layer Assesment with Cirrus Hd 5000 in Early Glaucoma

This study aims to assess the effectiveness of ganglion cell-inner plexiform layer (GCIPL) measurements in preperimetric glaucoma (PPG) and primary open angle glaucoma (POAG). GCIPL and retinal nerve fiber layer (RNFL) thickness were measured in PPG, POAG, and control groups. The data obtained from these three groups were compared with analysis of variance and post hoc Tukey test. Average GCIPL was 70.99±11.02 μm in PPG group, 68.95±11.93 μm. in POAG group, and 84.77±9.75 μm in control group. (p< 0.001). Average RNFL was 76.16±16.55 μm in PPG group, 70.33±21.02 μm in POAG group, and 98.13±11.48 μm in control group (P< 0.001). Pearson correlation coefficient between GCIPL and RNFL was r=0.59 (p<0.05) in POAG group, and r=0.51 (p<0.05) in PPG group. In conclusion, macular GCIPL thickness significantly decreases in PPG and POAG and this is correlated with RNFL decrease.